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First-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that . Jul 28,  · The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug metabolism. However, the first pass effect can also Author: Timothy F. Herman, Cynthia Santos. May 23,  · Examples of Drugs with Significant First Pass Effect or Low Bioavailability. Drug: Propranolol- ~26% Bioavailability because % is metabolized by the liver before it can reach the circulation when taken orally. Drug: Morphine- ~30% Bioavailability because 70% is metabolized via 1st pass effect if taken orally. Read more